Mammalian Wax Biosynthesis
نویسندگان
چکیده
منابع مشابه
Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.
Wax monoesters are synthesized by the esterification of fatty alcohols and fatty acids. A mammalian enzyme that catalyzes this reaction has not been isolated. We used expression cloning to identify cDNAs encoding a wax synthase in the mouse preputial gland. The wax synthase gene is located on the X chromosome and encodes a member of the acyltransferase family of enzymes that synthesize neutral ...
متن کاملBiosynthesis and secretion of plant cuticular wax.
The cuticle covers the aerial portions of land plants. It consists of amorphous intracuticular wax embedded in cutin polymer, and epicuticular wax crystalloids that coat the outer plant surface and impart a whitish appearance. Cuticular wax is mainly composed of long-chain aliphatic compounds derived from very long chain fatty acids. Wax biosynthesis begins with fatty acid synthesis in the plas...
متن کاملMammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.
The conversion of fatty acids to fatty alcohols is required for the synthesis of wax monoesters and ether lipids. The mammalian enzymes that synthesize fatty alcohols have not been identified. Here, an in silico approach was used to discern two putative reductase enzymes designated FAR1 and FAR2. Expression studies in intact cells showed that FAR1 and FAR2 cDNAs encoded isozymes that reduced fa...
متن کاملPlant cuticles shine: advances in wax biosynthesis and export.
The plant cuticle is an extracellular lipid structure deposited over the aerial surfaces of land plants, which seals the shoot and protects it from biotic and abiotic stresses. It is composed of cutin polymer matrix and waxes, produced and secreted by epidermal cells. The use of forward and reverse genetic approaches in Arabidopsis has led to the identification of enzymes involved in fatty acid...
متن کاملAnswering a four decade-old question on epicuticular wax biosynthesis.
In this issue of Journal of Experimental Botany (pages 2715–2730) Schneider et al. report the identity of three genes from barley described in the 1970s as important for the synthesis of β-diketone cuticular waxes, thereby revealing a novel polyketide synthase pathway responsible for their production. It is a perfect example of how modern sequencing technologies can resolve age-old questions on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m406225200